姜桂饮胶囊抗心肌缺血-再灌注损伤的生化机理研究

A study on biochemical mechanisms of Jiangguiyin capsules' actions against myocardial ischemia-reperfusion injury

目的研究姜桂饮胶囊抗心肌缺血的生化机理。方法采用急性心肌缺血-再灌注动物模型,观察姜桂饮胶囊对心肌组织中生化指标的变化,以及对血栓形成、纤维蛋白溶解、凝血时间的影响。结果姜桂饮可提高缺血区心肌谷胱甘肽过氧化物酶、超氧化物歧化酶活性,抑制丙二醛的含量升高,并可加快纤维蛋白溶解,抑制血小板凝集,延缓血栓形成。结论姜桂饮胶囊能够拮抗心肌缺血-再灌注损伤时氧自由基的产生,抑制血栓形成,对缺血心肌起到保护作用。

Objective Explore the biochemical mechanism of actions of Jiangguiyin capsules against myocardial ischemia and reperfusion injury. Methods Actions of Jiangguiyin capsules on alterations of biochemical indicators of peroxidation and effects of the capsules on thrombosis, fibrinolysis, and clotting time were observed in animal model of acute myocardial ischemia （AMI）-reperfusion injury. Results Jiangguiyin capsules can improve activities of glutathion peroxidase and superoxide dismutase （SOD）, accelerate fibrinolysis, while inhibit increasing of malondialdehyde level and platelet aggregation, and slow down thrombosis in ischemic heart muscle. Conclusion Jiangguiyin capsules can antagonize the formation of oxygen-derived free radicals, inhibit thrombosis, to protect ischemic heart muscle.