参宁栓抗炎、镇痛、止痒作用研究

Study on anti-inflammatory,analgesic,and antipruritic effects of Shengning suppository

目的探讨参宁栓的抗炎、镇痛、止痒作用。方法采用二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致大鼠足跖肿胀炎症模型,热板法和扭体法及磷酸组织胺的致痒试验,观察参宁栓的抗炎、镇痛、止痒作用。结果参宁栓对二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致大鼠足跖肿胀有显著的抑制作用,并能明显提高豚鼠对磷酸组织胺的致痒阈,对由热传导及化学性引起的疼痛有明显的抑制作用。结论参宁栓具有抗炎、镇痛、止痒作用,这些作用为参宁栓治疗湿热下注所致的带下、阴痒症提供了实验依据和药理学基础。

Objective To observe the anti-inflammatory, analgesic and antipruritic effects of Shengning suppository. Methods Analgesic effects of Shengning suppository were observed with pain model mice by acetic acid or hot plate test. Anti-inflammatory effects were studied with ear acute edema model induced by dimethylbenzene in mice and rat foot edema model induced by carrageen, and antipruritic action was observed with allergic pruritic model caused by histamine in guinea pigs. Results Shengning suppository could inhibit foot edema in rats and ear edema in mice. It also prolonged the period of pain reaction caused by hot plate in mice, decreased pain reaction induced with acetic acid and increased itching threshold value in guinea pigs. Conclusion Shengning suppository has obvious anti-lnflammatory, analgesic, and antipruritic effects.