摘要
目的:研究模拟失重对肺动脉反应性的影响,探讨立位耐力降低的发生机制。方法:采用尾悬吊模拟失重大鼠模型模拟微重力效应,制备离体肺动脉环测定其对几种血管活性物质的反应性变化。结果:与对照组相比,尾悬吊14d大鼠肺动脉对KCl(68mmol/L)和苯肾上腺素(10^-9-10^-5mmol/L)的收缩反应性明显下降,对乙酰胆碱(10^-9-10^-5mmol/L)的舒张反应性明显增强。结论:模拟失重14d后肺动脉收缩反应下降,舒张反应增强;肺动脉收缩反应的下降可能促进了立位耐力降低的发生。
Objective:To study the effects of simulated weightlessness on reactivity of pulmonary artery. Methods:Rat tail-suspension was used to simulate effects of microgravity. The changes in responses of pulmonary artery to several vasoactive agents were determined by using in vitro vessel rings perfusion technique. Results:Compared with the control group, the contractile responses of pulmonary artery to potassium chloride (KCl,68M) and phenylephrine ( PE, 10^-9 - 10^-5 M) were markedly diminished after 14day tail-suspension, while the vasoactive responses to acetylcholine( Ach, 10^-9- 10^-5M) were markedly enhanced. Conclusion: The contractile responsiveness is attenuated and the dilatory responsiveness is enhanced in the pulmonary arteries of rats after simulated weightlessness;impaired contractile responsiveness may contribute to orthostatic intolerance.
出处
《军医进修学院学报》
CAS
北大核心
2006年第6期434-435,共2页
Academic Journal of Pla Postgraduate Medical School
基金
武器装备预研基金项目(51400020104JB001)
"十五"军队医学科研基金重点项目(04Z020)
"十一五"军队医学科研专项基金资助项目(06Z048)
关键词
失重模拟
肺动脉
身体耐力
weightlessness simulation
pulmonary artery
physical endurance