“神农33”治疗急性间质性肾炎合并急性肾衰45例

Treating 45 Cases of Acute Renal Failure Induced by Acute Interstitial Nephritis with Shennong 33

目的:观察中药“神农33”注射液(简称“神农33”)治疗急性间质性肾炎(AIN)合并急性肾功能衰竭(ARF)的临床疗效及作用机制。方法:将75例入选病人随机分为治疗组45例和对照组30例,治疗组在西医综合治疗基础上加用“神农33”静脉滴注,对照组仅采用西医综合治疗。结果:治疗组总有效率为95.24%,对照组为80%,两组比较,差异有显著性意义(P<0.05);治疗组血肌酐(Scr)、尿素氮(BUN)恢复正常时间明显优于对照组,两组比较,差异有显著性意义(P<0.01);治疗组少尿总时间,治疗后少尿持续时间,血尿、蛋白尿转阴时间、血液透析平均次数,明显优于对照组,两组比较,差异有显著性意义(P<0.05)。结论:“神农33”对于AIN合并ARF具有良好的治疗作用。

Objectlve：To investigate the clinical effect and function mechanism of the Chinese medicine ＂Shennong33＂ in treating acute renal failure （ARF） induced by acute interstitial nephritis （AIN）. Methods：75 cases of ARF induced by AIN were randomly divided into the treatment group （45 cases） and the contrast group （30 cases）. Both groups were treated by normal western medine and the treatment group by the Chinese medicine ＂ Shennong33＂ additionally. Results：The total effect rates of the treatment group and the contrast group was 95.24% and 80.0% respectively. The difference had a significant meaning （P 〈 0.05）. The recover time of Scr and BUN in the treatment group was obviously better than that in the contrast group. The difference had a significant meaning （ P 〈 0.01 ）. The total time and the lasting time of less urine, the negative transferring time of hematuria and albuminuria, and the even time of hemodialysis in the treatment group were also better than those in the contrast group. The difference had a significant meaning （P 〈 0.05）. Conclusion： Shen- nong33 has a good curative effect in treating ARF induced by AIN.