滋阴明目丸对大鼠光损伤模型视网膜超微结构的影响

Effect of Ziyinmingmuwan on Ultrastructure of Rat Retina with Retinal Photic Injury

目的观察滋阴明目丸对视网膜光损伤大鼠的保护作用及机理。方法将70只Sprague-Dawley(SD)大鼠随机分为7组,除空白对照组外均采用自制光损伤装置造成视网膜光损伤模型,光照后3d开始灌服滋阴明目丸及对照药物,连续15d,取视网膜做病理形态学检查,观察视网膜超微结构变化。结果受损的视细胞逐步得到修复,视网膜形态结构渐趋正常。结论滋阴明目丸可改善视网膜超微结构。

Objective To investigate the protective effect and mechanism of Ziyinmingmuwan on retina against photic injury. Methods Seventy Sprague-Dawley （SD） rats were randomly divided into 7 groups, with 6 groups prepared as the models of phototrauma at first and another group taken as blank control, After three days, the animals in the treatment and control groups were treated with Ziyinmingmuwan and control agent respectively for 15 days during the period of experiment. Following this, the retinal tissues were examined by light and electron microscopy. Results The retinal lesions were repaired and the morphological structure of the retina was brought to normal gradually. Conclusion Ziyinmingmuwan could improve ultrastructure of the retina.