摘要
目的观察肿瘤坏死因子(TNFα)和超氧化物歧化酶(SOD)在溃疡性结肠炎动物模型血清及结肠粘膜中的活性变化。方法将大鼠随机分成对照组、实验组和实验治疗组,用大鼠TNFαELISA试剂盒和SOD试剂盒测定大鼠血清及肠粘膜中TNFα含量和SOD活力。结果①实验组血清及粘膜中TNFα含量明显高于对照组和实验治疗组(P<0.01);②SOD活力明显低于对照组和实验治疗组(P<0.01)。结论TNFα和氧自由基可通过多种途径介导肠粘膜的损伤。
Objective To study the change of TNTα and SOD activity during UC animal model scrum and colonic mucosa . Methods Rats were randomly divided into three goups： normal c- ontrol, experiment and treatment group. Investigate the change TNTα and SOD activity of rats serrum and mucosa with TNFα agent box and SOD agent box. Results （1） The content of TNTα of experiment group serum and mucosa was significantly higher than control and treatment （P〈0.01） ; （2） The activity of SOD was significantly lower than control and treatment （P〈0.01）.Conclusion TNFα and OFR may mvdiate injury of colonic mucosa by many pathways.
