抗肿瘤血管生成主动免疫治疗研究进展

Active antiangiogenic Immunotherapy for tumors

肿瘤血管生成在肿瘤生长、侵袭、转移中具有十分重要的作用。调控血管生成的因子很多，包括血管内皮细胞生长因子（VEGF）、成纤维细胞生长因子（FGF）、表皮细胞生长因子（EGF）等。近年来抗血管生成的肿瘤治疗已经取得较大进展，特别是抗肿瘤血管形成主动免疫治疗，已经成为抗肿瘤研究的热点。因而，以异种同源分子和非异种同源分子为疫苗的研究很有意义。

Tumor angiogenesis plays an important role in tumor growth, aggression, and metastasis. Many molecules are demonstrated as positive regulators of angiogenesis, including vascular endothelial growth factor （VEGF）, fibroblast growth factor （FGF）, epidermal growth factor （EGF）, etc. In recent years, significant progress has been made in the research on antiangiogenesis of tumors, especially, on active antiangiogenic immunotherapy for tumors. In this review, active antiagiogenic immunotherapies for tumors based on＇vaccination of xenogeneic homologous molecules and non-xenogeneic homologous molecules are discussed.