弥漫性泛细支气管炎HLA基因的研究进展

Research advance of HLA genes in diffuse panbronchiolitis

弥漫性泛细支气管炎（DPB）是一种两肺弥漫性呼吸性细支气管的气道慢性炎症性疾病。它的发病可能与亚洲黄种人所特有的某些基因有关，参与机体的免疫或变态反应。HLA是机体疾病易感性的主要遗传成分与人体免疫功能相关。目前研究表明，DPB疾病的HLA正相关基因主要为HLA—B5401，HLA＊A11等，负相关基因可能HLA＊B44与HLA—A33和HLA＊DRB1＊1302，而HLA Ⅲ类分子和此病无关，因而认为DPB疾病相关基因位点可能在HLA-B和HLA-A基因之间。

Diffuse panbronchiolitis （DPB） is a chronic pulmonary disease of diffuse inflammation in small airway, predominantly affecting Asian populations. It suggested that genetic factors involved in the immune reaction or inflammatory response in DPB. The human leukocyte antigen （HLA） system is essential for the immune responses and there are associations between HLA types and diseases. Some researches showed that HLA-B54 and HLA-A11 are positive associated with DPB. The frequency of HLA-A33, B44, DRB1 ＊ 1302 decreased in patients with DPB and were considered as negative association with DPB. There was no relation between HLA-Ⅲ genes and PBD. The HLA-associated genes for DPB are mainly located between HLA-A and HLA-B loci.