纳米铁粉对小鼠血糖和血脂的影响

THE EFFECT OF EXCESS NANO-SIZE IRON POWDR ON SERUM GLUCOSE AND LIPIDS IN MICE

[目的]探讨纳米铁粉对小鼠血糖、血脂的影响。[方法]分别以5g/kg剂量微米粒径铁粉(Micro-Fe)或纳米粒径铁粉(Nano-Fe)给小鼠1次经口灌胃,14d后处死;测定肝、肾脏器系数、血糖(Glu)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的变化。[结果]Micro-Fe和Nano-Fe染毒小鼠肝脏系数明显高于对照组相(P﹤0.05)。与对照组相比,Nano-Fe染毒小鼠血清Glu明显降低(P﹤0.05);Micro-Fe组血清TG比control组有明显升高(P﹤0.05),Nano-Fe组血清TG比control组有升高趋势,但差异无统计学意义(P﹥0.05)。Control、Micro-Fe和Nano-Fe染毒组3组小鼠血清TC、LDL-C和HDL-C水平间差异无统计学意义(P﹥0.05)。[结论]大剂量Nano-Fe经口染毒可使血清Glu降低,对TC、TG、HDL-C和LDL-C无明显影响。

[Objective] To explore the effect of nano-partieles iron on serum glucose and lipids in mice. [Methods] The raises were treated with the oral exposure dose in 5 g/kg of microor hans-size iron powder and executed 14 days later to be detected correlative serum biochemical indicators. [Results] The live/bedy eoeffeient of micro-and nano -size iron powder group were obviously higher than that of control group, The serum glucose of nano-size Iron powder group was lower than that of eontml group and micro-size Iron powder group sigrtificandy （P 〈 0.05） . The serum TG el micro-particles Iron group was obvionsly higher than that of control, though the TG of nano-parLicles Iron group was also higher than that of contol, there was no obvious difference between them （P 〉 0.05） . There were no any differences in serum TC, HDL-C and LDL-C among the control, micro- and hans-size iron group. [Conclusions] Large dose of the hans-size iron powder has greater effect on serum glucose but without any different effects on serum TG, TC, HLD-C and LDL-C compared with the ordinary iron material.