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核转录因子NF—κB/IκB信号通路与新月体性肾小球肾炎 被引量:4

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摘要 新月体性肾小球肾炎是一组由多种原因引起的、以肾小囊内毛细血管外细胞增殖为特征的炎症性肾小球病,一般认为新月体性肾小球。肾炎很快发展为终末期。肾衰竭。核转录因子KB(NF-κB)是一种多功能转录调节因子,可诱导包括调节各种免疫功能、细胞增殖及凋亡在内的调节分子基因表达。NF-κB及其抑制因子IκB在新月体性肾小球肾炎发病过程中的作用日益引起人们重视,本文拟就NF—κB/IκB信号通路在新月体性肾小球。肾炎发病过程中的作用的作一综述。
出处 《国际泌尿系统杂志》 2007年第1期112-116,共5页 International Journal of Urology and Nephrology
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