前列环素类药物治疗肺动脉高压的进展

Progress in the Use of PGI_2 for Treatment of Pulmonary Arterial Hypertension

研究显示前列环素减少和肺动脉高压的发生有关,前列环素类药物依前列醇、曲前列环素、贝前列环素、伊洛前列腺素均能降低肺动脉压力、肺血管阻力,增加心输出量、6min步行距离,同时无明显不良反应,从而改善肺动脉高压患者的症状和预后。

Studies have demonstrated that the lowering of PGI2 may cause pulmonary arterial hypertension. PGI2 drugs, such as epoprostenol, trcprostinil, beraprost, and iloprost can decrease pulmonary arterial pressure and pulmonary vascular resistance, increase Cardiac output and 6 minutes walk distance, while causing no obvious adverse reaction,so relieve symptoms and improve prognosis.