苦参素与干扰素治疗慢性乙型肝炎的成本-效果分析

Comparison of cost-effectiveness between matrine and interferon in treatment of chronic hepatitis B.

目的分析苦参素和干扰素α-1b治疗慢性乙型肝炎临床疗效,并进行经济学评价,为临床提供有效、实用治疗方案。方法63例慢性乙肝患者,采用随机分苦参素组和干扰素组,分析比较苦参素和干扰素α-1b的治疗成本和治疗效果。结果苦参素和干扰素α-1b治疗慢性乙型肝炎总有效率分别为70．97％和71．83％(P＞0．05)；成本-效果比分别为57．20和91．58(P＜0．05)；经敏感度分析所得的成本-效果比分别为45．76和73．26。结论苦参素与干扰素α-1b均能有效治疗慢性乙型肝炎,但前者比后者更经济,更符合药物经济学原则。

Objective To make pharmecoeconmios evaluation of matrlne and Interferon α-1β in treatment of chronic hepatitis B and to offer optimum schedule for clinical treatment. Methods Sixty - three chronic hepatitis B patients were randomly divided into treatment and control groups. Though phammcoeconmic cost - effectiveness analysis, the cost and efficacy of interferonα-1β was compared with matrlne in treatment of 63r chronic hepatitis B. Results The effective rates of matrine and interferon α-1β were 70.97 % and 71.83 % （ P 〉 0. 05） ;the cost - effectiveness ratios were 57.20 and 91.58 respectively （ P 〈 0. 05 ）. cest- effectiveness ratios obtained by sensitivity analysis were 45.76 and 73.26 respectively. ConeJwion Matrine is more economical than Interferon α-1β in lreatment of chronic hepatitis B patients.