影响狼疮性肾炎患者预后因素的探讨

A Clinic Study on Prognostic Factors in Patients with Lupus Nephritis

为探讨影响狼疮性肾炎（ＬＮ）患者肾存在活的主要因素，本文分析了８６例ＬＮ的临床、实验室及治疗有关资料，对各项临床参数进行单因素相关分析和多元回归分析。结果显示，血肌酐、尿素氮增高，尿β＿２－ＭＧ、ＩｇＧ增高。男性，病情反复加重次数增多，补体降低对五年肾存活具有明显不良影响；早期诊断、长期系统规划的激素、环磷酰胺治疗是提高肾存活率的关键。

To evaluate the clinic coursc and prognosis of lupus nephritis(LN) as well as to identify the risle factors for renal failure,86 patients with LN from 1980 loeve studied and the clinical and serologic parameters at the time of inital diagnosis were recorded.The results showed that those patients with male,increased eserum creatinine and BUN,increased urine β_2-MG and IgG,and decreased C3 complenent at initial diagnosis were prone to develop renal failure.The earliser diagnosis,earlier treatment,better supportive care,and lont time use of CTX Herapy may be of benefit to proghosis