摘要
蛋白体（proteosmes）是由B群2b型脑膜炎双球菌外膜蛋白中3个孔道蛋白形成的囊泡样大小不同的毫微粒结构体，具有疫苗投递载体和佐剂的特征。近几年，国外蛋白体佐剂应用在很多疫苗的研制中，并且具有突破性的进展，主要用于鼻内接种疫苗。本研究选用B群2b型脑膜炎奈瑟双球菌29353菌株，以不同培养条件优化蛋白体的提取，从稳定性和安全性的某方面检测蛋白体作为疫苗佐剂的可能性，为研制黏膜疫苗提供安全可靠的佐剂。
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2006年第12期1085-1086,共2页
Chinese Journal of Microbiology and Immunology
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