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乳腺癌细胞表皮生长因子受体、HER-2对雌激素受体的调控及三苯氧胺耐药机制

Regulation of Estrogen Receptor by EGF Receptor,HER-2 and Mechanism of Tamoxifen Resistance in Breast Cancer Cell
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摘要 雌激素受体(ER)在乳腺癌的发生和发展中起重要作用,抗雌激素治疗的内分泌治疗为重要的治疗方案,但易产生三苯氧胺(TAM)的耐药性而使治疗失效,原因之一可能是由于表皮生长因子受体(EGFR)和HER-2高表达引起ER磷酸化所致。本文概述了其中的分子机制和可能涉及的传导通路等。 Estrogen receptor（ER） plays important roles in progression of breast cancer, anti-estrogen is majors therapeutic method for breast cancer, but acquired resistance to tamoxifen in breast cancer patients is a serious problem, and the over expression of EGFR, HER-2 leading to phosphorylation of ER may be a major reason. The mechanism of molecular and related pathway of transduction was chiefly elucidated in this article.
作者 赵亚力 韩为东
机构地区 解放军总医院基础医学研究所分子生物学研究室
出处 《生物技术通讯》 CAS 2006年第6期939-941,共3页 Letters in Biotechnology
关键词 雌激素受体 表皮生长因子受体 三苯氧胺 estrogen receptor epidermal growth factor receptor tamoxifen
分类号 Q579.13 [生物学—生物化学] R737.9 [医药卫生—肿瘤]
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参考文献27

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二级参考文献31

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生物技术通讯
2006年 第6期

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