蛋白质相互作用的生物信息学研究进展

The Research Progress of Protein-Protein Interactions in Bioinformatics

生命过程的分子基础在于生物分子之间的相互作用,其中蛋白质分子之间的相互作用占有极其重要的地位。研究蛋白质相互作用对于理解生命的真谛、探讨致病微生物的致病机理,以及研究新药提高人们的健康水平具有重要的作用。用生物信息学的方法研究蛋白质的相互作用已经取得了许多重要的成果,但也有很多问题还需解决。本文从蛋白质相互作用的数据库、预测方法、可预测蛋白质相互作用的网上服务、蛋白质相互作用网络等几方面,对蛋白质相互作用的生物信息学研究成果及其存在的问题做了概述。

The interactions of biological molecules compose the molecular basis of biological processes, especially the interactions of proteins. Research of protein-protein interactions is vital to understanding the essence of life, finding the mechanism of diseases and developing new drugs to improve people＇s health. It has achieved many valuable results researching protein-protein interactions by bioinformatics but there are also some problems to be resolved. The research work of protein interactions from the databases of protein-protein interactions, the methods of predicting protein-protein interactions, the web-servers that can supply services of predicting protein-protein interactions and the research of protein interaction networks were reviewed in this article.