各型肝病检测血清透明质酸、层粘连蛋白的临床意义

DeterminationofthebloodserumHAandLNlevelsinhepatitis

测定６４例各型肝病患者血清透明质酸（ＨＡ）、层粘连蛋白（ＬＮ）水平，结果：慢活肝（ＣＡＨ）、代偿及失代偿肝硬化（ＬＣ）、慢重肝（ＣＳＨ）的血清ＨＡ及ＬＮ水平显著高于对照组及慢迁肝（ＣＰＨ），代偿及失代偿ＬＣ的ＨＡ水平显著高于ＣＡＨ；急肝（ＡＨ）患者ＬＮ全部正常，ＨＡ部分轻度升高，大多数ＣＰＨ患者ＬＮ、ＨＡ正常；代偿及失代偿ＬＣ、ＣＳＨ患者的ＨＡ水平＞３００ｎｇ／ｍｌ及１０００ｎｇ／ｍｌ者显著多于ＣＡＨ患者；ＬＮ水平＞１７０ｎｇ／ｍｌ的ＣＡＨ、代偿及失代偿ＬＣ和ＣＳＨ患者显著多于ＣＰＨ患者。提示：测定血清ＨＡ、ＬＮ水平对判定慢性肝病的严重程度意义重大，ＨＡ＞３００ｎｇ／ｍｌ、ＬＮ＞１７０ｎｇ／ｍｌ有助于鉴别ＣＡＨ及ＣＰＨ；ＨＡ＞１０００ｎｇ／ｍｌ时有助于鉴别ＣＡＨ及ＬＣ等。

evelsofbloodserumHAandLNin64patientswithhepatitisweremeasured.ResultsshowedthatthelevelsofbloodserumHAandLNinpatientswithCAH,withcompensatoryanddecompensatoryLC,andwithCSHarehigherthanthoseofcontrolsandwithCPH.ThelevelsofHAwithcompensatoryanddecompensatoryLCareobviouslyhigherthanthosewithCAH;thelevelsofLNinpatientswithAHarealnormal,butHAabithigher.LNandHAinmostpatientswithCPHarenormal;thelevelofHAinpatientswithcompensatoryanddecompensatoryLC,andwithCSHis>300ng/mland1000ng/ml,obviouslyhigherthanthosewithCAH;therearefarmorepatientswhoseLNlevels>170ng/mlwithCAH,withcompensatoryanddecompensatoryLCandCSHthanthosewithCPH.ItindicatedthatthedeterminationofbloodserumHAandLNlevelshasgreatsignificanceini-dentifythechronichepatitisdisease.HA>300ng/ml,LN>170ng/mlcanhelptoi-dentifyCAHandCPH;HA>1000ng/mlcanhelptoidentifyCAHandLC.