摘要
采用熔融法制备萘普生（Ｎａｐ）固体分散体，测定不同组份Ｎａｐ／ＰＥＧ体系的熔点，绘制共熔相图。测定固体分散体溶解度，溶出速率。结果表明：当Ｎａｐ与ＰＥＧ４０００（６０００）组份比１：４时出现低共熔现象。固体分散体可显著提高Ｎａｐ的溶解度及溶出速率。
Naproxen solid dispersion(NSD) was prepared by fusion method. The meltingpiont of NSD was determined and graphs of eutectic mixture phases of Nap in the system of PEG4000(6000)were drawn. The folubility and the dissolution rate were measured. The resultsshowed that the eutectic piont was obtained when the composition ratio of the disperion betweenNap and PEG was 1: 4. The soluhility and the dissolution rate of NSD were remarkably incremsed.
出处
《内蒙古医学院学报》
1996年第2期96-99,共4页
Acta Academiae Medicinae Neimongol
关键词
萘普生
溶解度
溶出速率
固体分散体
Naproxen
disperse systems, solid disperse
soluhility
dissolution rate
