干扰素-γ对宫颈癌细胞免疫分子表达的影响

Effect of interferon-γon expression of immune molecules on the cervical tumor cell

目的:研究干扰素-γ对宫颈癌细胞免疫分子表达的影响,探讨其在宫颈癌治疗中的免疫作用机制。方法:采用流式细胞术检测官颈癌细胞HLA-DR、CD80和CD40的表达。结果:干扰素-γ可增加宫颈癌细胞表面HLA DR和CD40的表达,对宫颈癌细胞表面CD80的表达无明显影响。结论:干扰素-γ抗肿瘤效应可能与上调宫颈癌细胞表面CD40和HLA DR分子表达有关。

Objective ：To study the effect of interferon-γ on expression of immune molecules on the cervical tumor cell and to investigate its mechanism in cervical cancer therapy.Methods：The expression of HLA DR,CD40 and CD80 on the tumor cell was detected respectively by flow cytometry.Results：Interferun-γincreased the expression of HLA DR and CD40 on the tumor cell,but not CD80.Conclusion： Anfitumor effect of Interferon-γis associated with the enhanced expression of HLA-DR and CD40 on the tumor cell surface.