细胞凋亡与食管贲门癌组织病理学特性的关系

Correlation between apoptosis and histopathological characteristics of esophageal and cardiac carcinoma

目的探讨细胞凋亡与食管、贲门癌组织病理学特性的关系．方法来用组织病理学方法检测３８例食管癌和４０例贲门癌手术切除标本癌组织中细胞调亡的状况，并进行定量分析，进而比较其与过组织的分化程度、浸润深度以及淋巴结转移之间的关系．结果食管、贲门边组织中均可见不同程度的细胞凋亡．并且细胞凋亡指数（即１０个高倍视野内凋亡细胞和凋亡小体数）与癌组织的分化程度及淋巴结转移有关（Ｐ＜０．０５），而与浸润深度无关（Ｐ＞ｏ．０５）．结论细胞调亡与食管、贲门癌的组织病理学特性有关．

Objective To investigate the correlation between aPOptosis and the histopothological charactel.istics of esophageal and cardiac carcinoma.Mchtods Quantitive analysis was performedfor apoptosis which was detected from therefections in 38 esophageal and 40 cardinccaf.cillomas with histopathological method, andthed apoptosis u:as compared with carcinomadit'ferelltiatioll alld infiltrating depth and lymphnode metal [as is.Results Tile apoptosis in defferential degreeti,.as observed in esopllageal alld cardiac carcinomatissues. APOpototic illdex (Al) (the number ofapoptolic cells alld apoptotic bodies per 10high-- pot-cper--fields) was well correlated with thedilTerelltiation and lymph node metastasis, but itti:as hot correlated t-c,ith the infiltrating depth.Conclllsil'n Apoptosis are well correlated withllistl'patbological charactel.istics of esophageala 11d card tao ca rot 11o ma.