摘要
以邻甲基苯乙酮为原料,经过高锰酸钾的碱性氧化,甲醇酯化,再与甲氧基胺盐酸盐肟化后,用N-溴丁二酰亚胺(NBS)溴化,最后和间三氟甲基苯乙酮肟缩合得到目标产物肟菌酯。产品的纯度大于96%(HPLC法),总产率达到20%。
Study on an efficient process for the preparation of trifloxystrobin starting from 2-methylacetophenonc by partial oxidation, estcrification, reaction with mcthoxyamine, bromization and condensation with 3＇-（trifluoromcthyl） acetophenone oxime. The purity of the product was over 96% （by HPLC）. The total yield was more than 20% based on 2-mcthylacctuphenone.
出处
《农药》
CAS
北大核心
2007年第1期29-30,35,共3页
Agrochemicals
关键词
肟菌酯
邻甲基苯乙酮
杀菌剂
合成
trifloxystrobin
2-methylacetophenone
fungicide
synthesis
