摘要
目的：研究八氯二丙醚对胚胎是否具有致畸性。方法：采用传统致畸试验方法。结果：八氯二丙醚在每１ｋｇ体重８０、３２０和１６００ｍｇ的染毒剂量条件下，没有发现明显的致畸作用。但是１６００ｍｇ／ｋｇ的剂量对孕鼠和胎鼠都有一定的毒性作用。该组胎鼠体重最小而胎盘最重，低剂量组胎鼠的体重和身长均高于阴性对照组。经统计学检验差异均有显著性。
Aim :To study the teratogenicity of octachlorodipropylether.Method :Traditional teratogenic test was used.Result :There was no evidence of malformation at the dose of 80、320 and 1600mg/kg.Certain toxicity was found in the 1600mg/kg group in which the baby rat was the lightest in wight and the plate was the heaviest.The weight and the length of baby rats in 80mg/kg group were greater than those in negative group( P <0.01).Conclusion :No teratogenicitic effect was found.
出处
《南京铁道医学院学报》
1996年第4期232-234,共3页
Journal of Nanjing Railway Medical College
基金
铁道部青年基金
关键词
八氯二丙醚
致畸性
大鼠
octachlorodipropylether
teratogens,rats
