摘要
目的：检测被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）肾小球基底膜电荷屏障的变化。方法：将含肾小管抗体的抗血清腹腔注射于大鼠体内建立被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）模型。用聚乙烯亚胺作为示踪剂，在电镜下观察ＰＨＮ大鼠肾小球基底膜阴离子位点的变化。结果：ＰＨＮ大鼠肾小球基底膜阴离子位点明显减少。结论：在ＰＨＮ中。
Objective :To investigate the glomerular charge barrier change in passive heymann nephritic(PHN) rats.Method :Polyethyleneimine(PEI) was used as tracing marker to observe the anionic sites in glomerular basement membrane(GBM) by electronmicroscope.Result :Anionic sites in GBM of PHN rats were fewer than those of normal rats.Conclusion :There may be a glomerular charge barrier damage in PHN that causes proteinuria.
出处
《南京铁道医学院学报》
1996年第4期240-243,共4页
Journal of Nanjing Railway Medical College
关键词
肾炎
PHH
肾小球基底膜
电荷屏障
聚乙烯亚胺
passive heymann nephritis
glomerular basement membrane
charge barrier
polyethyleneimine(PEI)
