临沂市中小学生重组酵母乙型肝炎疫苗接种效果

Effect of Gene Recombining Hepatitis B Vaccination

目的评价重组酵母乙型肝炎疫苗（以下称乙肝疫苗）在临沂市中小学生中大规模接种后的效果。方法采用随机整群抽样法，选择兰山区中小学各1所。小学1—6年级和中学初一到高三的6—18岁1829名学生，接种重组酵母乙肝疫苗。1年后，采用ELISA检测血清中HBsAg、抗-HBc、抗-HBs。结果乙肝疫苗接种前后乙肝病毒标志物（HBVM）阳性率差异有统计学意义（x^2=236．66，P〈0．01）；HBVM中，接种后抗-HBs阳性率显著高于接种前（x^2=205．42，P〈0．01）；接种前后HBsAg总感染率、抗-HBc总感染率差异无统计学意义。结论中小学生大规模接种的效果较好，低年龄组人群应为乙肝疫苗大规模接种的优选对象。

[ Objective] To evaluate the effect of gene recombining hepatitis B vaccination. [ Methods] Stratified multi - stage cluster sampling was used to select 1829 students between 6 and 18 years old from a middle school and a primary school of Lanshan District ; ELISA was applied to determine serum HBsAg, anti - HBc and anti - HBs of the students 1 year after vaccination with gene recombining hepatitis B vaccine. [ Results] There was notable statistical significance between pre- immunization and after- immunization in the positive rate of HBVM （P 〈0. 01 ）. The positive rate of anti - HBs after immunization was significantly higher than that before immunization （P 〈0. 01）. No statistical significance Was found in the total infectious rate of HBs and anti -HBc. [ Conclusion] The effect of massive gene recombining hepatitis B immunization among middle school and primary school students has been proved to be fine; the low - age population should be considered as the priority for massive hepatitis B vaccination.