摘要
为了研究特发性癫痫的流行病学特征及遗传方式,作者结合家系分析,多基因检验等方法,研究了山东省遗传病调查中发现的210个特发性癫痫(IEP)大家系.结果表明,IEP的一级亲属患病率(32.11%)明显高于群体患病率(0.80%),表明IEP有遗传因素的影响.家系分析及多基因分析表明IEP为常染色体隐性遗传.在不同亲缘的子女患病率方面没有发现基因印迹现象.
The authors studied 210 pedigrees with idiopathic epilepsies (IEP) of the population survey data in Shandong Province, using genetic epidemic methods such as familial analysis and tests for multifactoriol inheritance. The results indicate that there are genetic factors influencing IEP which has no onset peak in old age. The calculated results also show IEP is recessive disorders and there is no genomic imprinting phenomena in the prevelence of offsprings in origins between affected father and mother.
出处
《潍坊医学院学报》
1996年第4期250-253,共4页
Acta Academiae Medicinae Weifang
关键词
特发性
癫痫
基因印迹
多基因分析
idiopathic epilepsy
autosomal recessive inheritance
genomicimprinting
tests for multifactoriol inheritance
