复方甘草酸苷注射液联合护肝片治疗抗结核药物性肝炎的疗效

Efficacy of compound glycyrrhizin injection plus tablets for liver prophylaxis for inpatients with hepatitis induced by anti-tuberculosis drugs

目的:观察复方甘草酸苷注射液联合护肝片治疗抗结核药导致肝损害的疗效。方法:将216例抗结核药导致肝功能损害的患者随机分成试验组和对照组各108例,前者用复方甘草酸苷注射液40mL+5%葡萄糖注射液250mL,静滴,qd,加护肝片口服3粒,tid。后者用常规疗法:肝泰乐注射剂0．399g+维生素C注射剂1．0g+ 5%葡萄糖注射液250mL,静滴,qd。结果:结核药物性肝炎大多发生于强化期内,试验组在临床症状、体征、肝功能的改善方面(86．7%)较对照组(71．4%)有显著性差异(P＜0．05)。治疗结束后试验组总有效率为100%,对照组为88．9%,两组间比较有显著性差异(P＜0．05)。结论:复方甘草酸苷注射液联合护肝片治疗1周内,可明显改善药物性肝炎表现及恢复肝功能作用,对于结核药物性肝炎有较高疗效且临床应用安全。

Objective： To evaluate the efficacy of compound glycyrrhizin for injection combined with the tablets for liver prophylaxis for patients with hepatitis associated with anti-tuberculosis drugs. Methods ： 216 inpatients with liver dysfunction due to anti-tuberculosis drugs were randomly 1 ： 1 assigned into one of two treatment regimens： compound glycyrrhizin for injection 40 mL and 5% glucose solution 250 mL （iv gtt, qd） and the tablets for liver prophylaxis （tid, oral） , or conventional therapy combined with sodium glucuronic acid for injection 0. 399 g and Vc 1.0 g and 5% GS 250 mL （iv gtt, qd）. Results： The concomitant hepatitis with anti-TB agents mostly occurred in the enhance period. The patients administering compound glycyrrhizin and the conventional therapy experienced improvements rate of 86.7% vs. 71.4% in improvement of physical symptoms/signs and hepatic function parameters and the overall efficacy rate of 100% vs. 88.9% ; the P values were statistically different （P 〈0.05）. Conclusion： Compound glycyrrhizin injection combined with the tablets for liver prophylaxis offered an effective and safe option for patients with hepatitis due to anti-tuberculosis agents.