IgG抗-A+B对新生儿高胆红素血症发生率的影响

A study of the influence about the Ab-A+B immunoglobulin to the hyperbilirubinemia which the neonates developing

目的探讨IgG抗-A+B对“A”或“B”型新生儿高胆红素血症发生率的影响。方法对“O”型血孕妇分娩的“A”或“B”型新生儿脐血进行血型血清学检验,按是否存在IgG抗-A+B进行分组,调查其高胆红素血症的发生率。结果(1)抗体释放试验阳性患儿与对照组新生儿高胆红素血症发生率差异有统计学意义(P<0.01)。(2)抗体释放试验阳性结果中,存在与不存在IgG抗-A+B的患儿高胆红素血症发生率差异无统计学意义(P>0.05)。(3)在脐血IgG抗-A+B阳性的患儿中,未发病组患儿IgG抗-A+B致敏红细胞破坏的数量极显著高于新生儿溶血病组患儿(P<0.01)。结论新生儿溶血病是导致新生儿发生高胆红素血症的病因,IgG抗-A+B对新生儿高胆红素血症发生率无显著影响。

Objective To research into the influence about the Ab-A ＋ B immunoglobulin to the hyperbilirubinemia in the A or B blood-type neonates. Methods The serology with umbilical blood of the neonates who were delivered by the O-type-blood mother and whose blood-type was A or B were determined. Grouping according to the presence or not of the Ab-A ＋ B immunoglobulin, the morbidity of hyperbilirubinemia was studied. Results （1）Determining the morbidity of hyperbilirubinemia; It put up an extremely remarkable difference comparing the antibodyreleased test result being positive group to the control group（ P 〈 0.01 ）. （2）In the antibody-released test result being positive group, the incidence of hyperbilirubinernia put up no remarkable difference whether it presented Ab-A ＋ B or not（ P 〉0.05）. （3）In the neonates whose umbilical blood presented Ab-A ＋ B, comparing the healthiness group to the HDN group, the quantity of the wrecked erythrocyte which sensitized by the Ab-A ＋ B immunoglobulin was more excessive（ P 〈 0.01 ）. Conclusion HDN is the origin of hyperbilirubinemia and the Ab-A ＋ B immunoglobulin shows no remarkable influence to the hyperbilirubinemia.