^(131)Ⅰ治疗非Graves’甲状腺功能亢进及非毒性甲状腺肿后诱发Graves’病

Induction of Graves'disease in patients with non-autoimmune hyperthyroidism or nontoxic goiter after radioiodine treatment

^(131)I治疗非Graves’甲亢及非毒性甲状腺肿后数月,少部分患者体内出现促甲状腺激素受体抗体并诱发Graves’病(GD),发病率在0．05%～5%之间。其发病机制假说有通过自身免疫反应介导等。通过监测体内甲状腺自身抗体水平变化、甲状腺显像,可以预测^(131)I治疗后GD的发生。其治疗方法有抗甲状腺药物治疗、再次放射性^(131)I治疗、手术治疗。

Thyrotropin receptors antibodies may occur and induce Graves＇disease （GD） several months after radioiodine therapy in a small number of patients with nontoxic goiter. The prevalence of radiation-induced GD is between 0.05% and 5%. The hypothesis of this disease includes induction by autoimmune reaction and others. Detection of the thyroid autoantibodise or of ^99mTc pertechnetate scan can forecast the appearance of GD. Anfithyroid drugs,again radioiodine therapy and surgery are the treatments.