摘要
目的:观察甘氨双唑钠(CMNa)对食管癌根治性放疗后复发再程放疗的放射增敏作用及不良反应.方法:2001-07/2003-06,收治食管癌放疗后局部复发行再程放疗的患者46例,均为首程放疗结束后疗效达到基本痊愈或明显缓解者,一段时间后又出现吞咽情况恶化等临床症状,经病理检查确诊为复发,随机分为研究组和单放组,每组23例,研究组:CMNa800mg/m^2,用生理盐水100mL稀释溶解后静脉输入,输入结束后60min内进行放射治疗,3次/wk,从再程放疗开始连续用药至放疗结束.两组患者均采用加速器6MV-X线,体外等中心常规放疗或三维适形放疗,每次2Gy,5次/wk,照射剂量50~66Gy.对比两组近期疗效、局部控制率、生存率及毒副反应差别.进行X线和CT检查客观评价.结果:研究组近期有效率(CR+PR)73.9%,单放组为43.5%(P〈0.05).两组的1,2,3a局控率分别为65.2%,39.1%,30.4%和43.5%,17.4%,8.7%(P〈0.05);1,2,3a生存率分别为87.0%,47.8%,34.8%和69.6%,21.7%,13.0%(P〈0.05).结论:CMNa可以增加食管癌放疗后复发病灶的放射敏感性,放疗合并使用CMNa可提高食管癌根治性放疗后复发的近期疗效、局部控制率及生存率.
AIM: To investigate the sensitivity enhancement of sodium glycididazole (CMNa) in re-radiotherapy against local recurrent esophageal carcinoma after radical radiotherapy. METHODS: Such cases (n = 46) who recurred after they had received radical radiotherapy and were confirmed by pathology from July, 2001 to June, 2003 were divided randomly into study group and control group. Before re-radiotherapy, the patients in study group were treated by intravenous infusion of CMNa 800 mg/m^2 diluted in 100 mL sodium chloride, 3 fractions a week through the total therapy course. The radiotherapy was carried out 60 min after each infusion. All patients received conventional radiotherapy or three dimensional conformal radiotherapy at 2. 0 Gy each time, 5 fractions a week to a total dose of 50 - 60 Gy. The short-term therapeutic effect, local control rate, survival rate and side effects were compared in the 2 groups. CT and barium meal examinations of esophagus were performed. RESULTS : The short-term effective rates (CR + PR ) were 73. 9% in study group, 43.5% in control group ( P 〈 0.05 ). The 1-, 2- and 3- year local control rates were 65.2%, 39. 1% and 30.4% in study group, 43.5%, 17.4%, and 8.7% in control group (P〈 0.05). The 1-, 2- and 3-year survival rates were 87. 0%, 47.8% and 34.8% in study group, 69.6%, 21.7% and 13.0% in control group (P 〈0.05). The incidence rates were not found different among the 2 groups. CONCLUSION: CMNa can enhance the radiosensitization of the local recurrent esophageal carcinoma cells. Re-radiotherapy combined with CMNa can improve the short-term effective rates, local control rate and survival rate of the patients with local-recurrent esophageal carcinoma after radical radiotherapy.
出处
《第四军医大学学报》
北大核心
2007年第1期39-41,共3页
Journal of the Fourth Military Medical University
关键词
食管肿瘤
复发
放射治疗
增敏剂
esophageal neoplasms
local recurrence
radiotherapy
sensitizer