组蛋白去乙酰化酶抑制剂与炎症免疫性疾病

Histone deacetylase inhibitors and inflammatory-immune diseases

组蛋白去乙酰化酶抑制剂已经越来越多的被用于治疗肿瘤和白血病。近年来,组蛋白去乙酰化酶抑制剂作为潜在的抗炎免疫药为类风湿关节炎或红斑狼疮等的治疗提供了一种新的思路,它在炎症免疫性疾病中的作用机制越来越受到人们的关注。

Histone deacetylase inhibitors had been used to treat cancer and leukemia. In recent years, Histone deacetylase inhibitors have emerged as potent contenders for anti-inflammatory drugs, offering new lines of therapeutic intervention for rheumatoid arthritis or lupus erythematosus. The mechanism of histone deacetylase inhibitors in inflammatory-immune diseases has been paid more and more attention.