纳洛酮治疗COPD慢性呼吸衰竭60例的临床疗效

Clinical investigation of nalaxone in treatment of 60 cases with chronic obstructive pulmonary disease and chronic respiratory failure

目的观察纳洛酮在COPD呼吸衰竭患者出现呼吸抑制的临床疗效。方法120例入选者随机分为对照组和治疗组(在对照组治疗的基础上加用纳洛酮),对比观察抢救成功率和死亡率及治疗前后血气变化。结果治疗组抢救成功率达85%,死亡率15%,与对照组相比有显著差异(P<0·01)。讨论纳洛酮抢救慢性呼衰患者的呼吸抑制不失为一种安全有效的方法,值得临床推广应用。

Objective To investigate the clinical efficacy of naloxone in chronic obstructive pulmonary disease （COPD） with chronic respiratory failure with respiratory inhibition. Methods One hundred and twenty cases were divided into two groups at random： treatment group and control group. The treatment group was given naloxone in addition to the regular therapy given in the controls. The mortality rate and remission rate were measured. Results Compared with the control group, the remission rate in the trvatment group was 85%, which was significantly higher than that in the control group：P 〈0. 01. The mortality rate in the treatment group was 15%, which was significantly lower than that in the control group：P 〈 0. 01. Conclusion Naloxone is a safe and effective drug in treating respiratory failure with respiratory inhibition.