脑白质疏松患者血清VEGF水平的研究

Study on the level of vascular endothelial growth factor in patient with leukoaraiosis

目的探讨血管内皮生长因子(VEGF)在脑白质疏松(LA)患者中的临床意义。方法用酶联免疫分析法测定45例LA患者和20例健康人血清VEGF的含量。将LA患者根据其严重程度分为4级,同时又根据是否合并脑梗死分为伴脑梗死组与不伴梗死组,然后比较不同级别和不同组别患者的血清VEGF的含量。结果除LAI组患者血清VEGF的含量与正常对照组比较无统计学意义外,其余3组的VEGF含量均显著高于正常对照组(P<0.01),而且随脑白质疏松严重程度的加重而血清VEGF的含量也随之明显升高(P<0.05或P<0.01)。伴脑梗死组LA患者血清VEGF含量明显高于不伴脑梗死组(P<0.01)。结论VEGF与LA的发生发展有着一定的关系,血清VEGF含量可以反映LA的严重程度以及脑缺血的严重性。

Objective To explore the clinical signiilcance of VEGF in patients with leukoaraiosis （LA）. Methods Enzyme-linked immunosorbent assay （ELISA） was used for detennination of VEGF contents in blood serum in 45 patients with LA and 20 healthy persons. The patients with LA were divided into 4 grades according to degree of leukoaraiosis, and were also divided into two groups in which ＇one with cerebral infarction and the other without cerebral infarction. Then the contents of VEGF in different grades and groups were compared. Results The contents of VEGF in the patients with LA were significantly higher than that in control group （ P 〈 0.01 ）, except LA I group, further- more the content of VEGF were gradually increased along with degree of leukoaraiosis （ P 〈 0.01 or P 〈 0.05） .The content of VEGF in group with cerebral infarction were significantly higher than that in group without cerebral infarction （ P 〈 0.01）. Conclusion VEGF is related to the occurrence and development of LA.VEGF contents in blood serum indicates the degrees of LA and severity of cerebral ischemia.