羟乙膦酸钠治疗老年骨质疏松性骨折临床观察

Clinical observation of etidronate disodium in treating senile osteoporosis fracture

目的观察抗骨质疏松药物羟乙膦酸钠对老年骨质疏松性骨折的治疗效果。方法统计分析2000-2004年5092岁(平均66岁)髋部骨折患者200例(部分因合并心脑血管、糖尿病等致死亡或不愈合的特殊病例除外),其中手术内固定120例,非手术治疗80例,都应用羟乙膦酸钠0.4g/d,两餐间或睡前服,15d为一疗程,间隔2个月重复应用,间隔期间补充钙剂及维生素D。并统计相应对照组,手术治疗100例,非手术治疗80例,未用羟乙膦酸钠。观察骨折临床愈合和功能恢复时间。结果手术内固定组平均临床愈合时间应用羟乙膦酸钠组为24周,对照组为29周;非手术组平均临床愈合时间应用羟乙膦酸钠组为16周,对照组为20周。结论羟乙膦酸钠对老年骨质疏松性骨折有明显促进愈合和恢复功能。同时非手术治疗由于避免了术中血运的进一步破坏,对骨折的愈合有重要的意义。

Objective To investigate the curative effect of anti-osteoporosis drug etidronate disodium on senile osteoporosis fracture. Methods 200 cases of pelvic bone fracture aged 50-92 years（average 66 years） were statistically analyzed between 2000 and 2004 （excluding those special eases died of combined cardiovascular, diabetes or unhealed）. Among them, 120 cases received operative internal fixation,80 cases adopted non-operative treatment and repeated the treatment within 2 months. Caleuim and vitamin D were supplemented during the interval. In the control group, 100 eases were operatively cured, 80 cases adopted non-operative treatment without use of etidronate disodiurn. The clinical fracture heal and the time of functional recovery were observed. Results The average clinical heal time of operative internal fixation group： etidronate disodium application group was 24 weeks,the control group was 29 weeks. Average clinical heal time of non-operative group： etidronate disodium group was 16 weeks, the control group was 20 weeks, Conclusion Etidronate disodium can evidently hasten heal and functional recovery of senile osteoporosis fracture, Because of avoiding progressive destruction to intraoperative blood circulation, non-operative treatment is important to fracture heal.