蛇葡萄根软膏抗炎镇痛药效学实验研究

Pharmacodynamic study on anti-inflammation and pain-relieving effects of Ampelopsis sinica Ointment

目的:研究蛇葡萄根软膏抗炎、镇痛的药效学。方法:抗炎实验采用小鼠耳廓肿胀法,镇痛实验采用小鼠热板法和扭体法。结果:蛇葡萄根软膏对二甲苯所致的小鼠耳廓肿胀有明显的抑制作用,与赋形剂组比较差异极显著(P<0.01),与阿昔洛韦组比较差异显著(P<0.05);热板法镇痛与赋形剂组相比,镇痛效果显著(P<0.01),对于醋酸所致的扭体反应次数明显减少(P<0.01)。结论:蛇葡萄根软膏有一定的镇痛、抗炎作用,具有深入研究价值。

Objective：To study the anti-inflammatory and pain-relieving effect ofAmpelopsis sinica ointment. Methods：The experiment were carded out in model mice. The inflammation model were induced by ear swelling caused by dimethylbenzene. The pain model were developed with hot-plate procedure and wring body caused by acetic acid. Results：The difference of effect between Ampelopsis sinica ointment group and the control group were extreme significant （P〈0.01） in anti-inflammation test, while in mice hot-plate test and wring body test, the difference were also significant （P〈0.01）. Conclusion： The antiinflammatory and pain-relieving effects ofAmpelopsis sinica ointment were promising and valuable to be studied further.