(R)-2-甲基吡咯烷的合成

Synthesis of (R)-2-Methylpyrrolidine

(R)-N-三苯甲基丙氨醛经Wittig-Horner反应和催化加氢反应制得(R)-5-甲基-2-氧代吡咯烷,再用硼烷-二甲硫醚还原得到(R)-2-甲基吡咯烷,总收率63%。

（R）-2-Methylpyrrolidine was synthesized from （R）-2-（tritylamino）-propionaldehyde by Wittig-Homer reaction and catalytic hydrogenation to give （R）-5-methyl-2-oxopyrrolidine, which was subjected to reduction with borane-dimethylsulfide with an overall yield of 63 %.