哮喘神经机制的研究进展

The Development of neuromechanism in asthma

支气管哮喘（哮喘）是全球性的严重健康难题，发病机制错综复杂，至今仍不完全清楚。现在被较多学者接受的理论是气道慢性炎症学说、变态反应学说、气道高反应学说以及气道重构学说。其中气道慢性炎症、高反应性和气道重构均涉及到神经机制的参与。越来越多的研究发现神经机制在哮喘气道高反应性中起至关重要的作用，并与免疫机制相互作用，引起神经源性炎症反应。对神经机制的研究可能成为未来攻克哮喘难关的突破点。

Bronchial asthma（asthma） is a tough problem all over the world. The pathogenesis of asthma is complicated and still has been undetermined so far. Now more acceptable theories on asthma are the theories of airway chronic inflammation, allergic reactivity, airway hyperresponsiveness and airway remodeling. And the neuromechanism may take part in the process of airway chronic inflammation, airway hyperresponsiveness and remodeling. More and more investigations have found that neuromechanism plays a critical role in the airway hyperresponsiveness in asthma, and may interact with immunomechanism to induce neuroinflammation. The study on neuromechanism could be the breakout of asthma in future.