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磷脂酰肌醇3激酶与肺部疾病 被引量：4

The phosphoinositide 3-kinase pathway in pulmonary disease
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摘要 近年来发现磷酯酰肌醇3激酶（phosphoinositide 3-kinase，PI3K）及其下游信号分子与某些肺部疾病关系密切，本文概述了PI3K的结构、分类、信号调节、生物学功能及其在支气管哮喘、肺癌等肺部疾病中的作用。 The Phosphoinositide 3-Kinase （PI3K） and its downsteam signaling molecule is recently discovered to have a close relationship with some pulmonary diseases. This article review PI3K about its structure, typing, signaling regulation, biological function and its role in asthma, lung cancer and other pulmonary diseases.
作者 孔志斌 王鸿程
机构地区 泸州医学院附属医院呼吸内科
出处 《国际呼吸杂志》 2007年第1期67-70,共4页 International Journal of Respiration
关键词 哮喘 肺癌 肺疾病 Asthma Lung cancer Pulmonary diseases
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献22

  • 1Cantley LC.The Phosphoinositide 3-Kinase Pathway.Science,2002,296:1655-1657.
  • 2Condliffe Am,Cadwauader KA,Walker TR.PI3K:a critical signaling event in pulmonary cells.Respir Res,2000,1:24-29.
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二级参考文献27

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共引文献13

同被引文献34

  • 1Temelkovski J, Hogan SP, Shepherd DP, et al.An improved murine model of asthma:selective airway inflammation,epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen[J]. Thorax,1998,53(10):849-856.
  • 2Lin CH,Yeh SH,Lin CH,et al. A Role for PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala[J].Neuron,2001,31 (5): 841-851.
  • 3Myou S,Leff AR,Myo S,et al.Blockade of inflammation and airway hyperresponsiveness in immune sensitized mice by dominant negative phophoinositide 3-kinase-TAT[J].Exp Med,2003,198(10): 1573-1582.
  • 4Farghaly HS, Blagbrough IS, Medina-Tato DA,et al. Interleukin 13 Increases Contractility of Murine Tracheal Smooth Muscle by a Phosphoinositide 3-kinase p110 δ Dependent Mechanism [J]. Mol Pharmacol,2008,73(5):1530- 1537.
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  • 6Fukao T, Tanabe M, Terauchi Y, et al. PI3K mediated negative feedback regulation of IL-12 production in DCs [J]. Nat lmmunol,2002,3(9):875-881.
  • 7Ward SG, Finan P. Isoform specific phosphoinositide 3- kinase inhibitors as therapeutic agents [J].Curr Opin Pharmacol,2003,3(4):426-434.
  • 8Condliffe A M, Cadwauader K A, Walker T R. PI3K: acritical signal in gevent pulmonary cells[J]. Respir Res, 2000, 1: 24-29.
  • 9Temelkovski J, Hogan S P, Shepherd D P, et al. An murine model of asthma:selective airway inflammation lesions and increased methacholine responsiveness chronic exposure to aerosolised allergen[J]. Thorax, improved , epithelial following 1998. 53:849-856,.
  • 10Chih-hung Lin, Shiu-Hwa Yeh, Chia-Ho Lin, et al. A Role for PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala[J]. J Neuron, 2001, 31: 841- 851.

引证文献4

二级引证文献18

国际呼吸杂志
2007年 第1期

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