持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征患者胰岛素抵抗的影响

Effect of continuous positive airway pressure on insulin resistance in patients with obstructive sleep apnea hypopnea syndrome

目的探讨持续气道正压通气(CPAP)对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者胰岛素抵抗的影响。方法选择中重度OSAHS患者20例作为实验组,并设正常对照组20例,分别测定空腹血糖、空腹血浆胰岛素,并对OSAHS患者进行CPAP治疗3个月,治疗后再次测定空腹血糖、空腹血浆胰岛素。结果1OSAHS患者空腹血糖、空腹血浆胰岛素显著高于对照组(P<0.05),胰岛素敏感性指数显著低于对照组(P<0.05);2CPAP治疗3个月后,空腹血浆胰岛素较治疗前显著下降(P<0.05),胰岛素敏感性指数较治疗前显著提高(P<0.05)。结论CPAP治疗能显著提高OSAHS患者胰岛素敏感性,从而改善OSAHS患者胰岛素抵抗。

Objctive：To explore the effect of continuous positive airway pressure on insulin resistance in patients with obstructive sleep apnea hypopnea syndrome （OSAHS） Methods： 20 patients with moderate to severe OSAHS were selected as trial group ,and 20 normal subjects as control group . fast blood sugar and fast blood insulin were detected in two groups ,and OSAHS group were treated with three months of continuous positive airway pressure （CPAP） therapy . After CPAP therapy ,fast blood sugar and fast insulin were detected again. Results： ①Fast blood sugar and fast blood insulin were significantly higher in OSAHS group than in control group （P〈0. 05） ,while insulin sensitive index （ISI） was significantly lower in OSAHS group than in control group （P〈0. 05） ②After three months of CPAP therapy , fast blood insulin was significantly decreased and ISI was significantly increased （P〈 0. 05） . Conclusion： CPAP can increase insulin sensitive index and improve insulin resistance in OSAHS patients.