碳酸钙生物矿化的体外研究进展

Review of the function of calcium carbonate in biomineralization in vitro

研究生物矿化的机理,可以为仿生制备新材料提供理论依据和合成手段,而碳酸钙是生物矿化的主要无机体系之一。近年来碳酸钙的体外研究使用了生物提取的或者人工合成的添加剂和模板,调控出了不同的碳酸钙晶型以及特殊的晶粒形貌,对于有机无机界面诱导矿化的机理给出了更多的原子水平的分析和验证,这些进展已经逐渐将生物矿化的研究带入了仿生的机理模拟阶段。在一些最新的研究成果中,使用微印法控制结晶位点,或者使用原子力显微镜观察微观生长形貌,或者从相转变角度认识矿化过程,这些研究为矿化研究今后的发展提供了新方向。

Improved understanding of the biomineralization mechanism will inspire new ideas for biomimetic materials. Calcium carbonate is one of the most important minerals in biomineralization. Recent in vitro studies of calcium carbonate have used selected additives and templates to control polymorphs and the morphologies of the crystals. This paper reviews the atomic scale studies of organic/inorganic interfacial functions which promote understanding of the biomineralization mechanism. This paper also reviews new viewpoint such as phase transformation, and new experimental methods such as micro-printing and atomic force microscopy.