MUC1在腺性膀胱炎与膀胱腺癌中的表达及其意义

MUC1 EXPRESSION IN CYSTITIS GLANDULARIS AND ADENOCARCINOMA

目的:探讨上皮特异性粘蛋白(MUC1)在腺性膀胱炎和膀胱腺癌的表达及其意义。方法:应用免疫组织化学SP法检测20例正常膀胱黏膜、20例腺性膀胱炎和10例膀胱腺癌组织中MUC1的表达,分析其表达特点。结果:正常膀胱黏膜、腺性膀胱炎和膀胱腺癌组织均有MUC1阳性表达,但表达量、模式均不同,且MUC1表达类型与组织增生、癌细胞分化有关(P<0·001)。结论:MUC1的高表达反映黏膜上皮代谢活跃的增生特征,并不是恶变的标志。腺癌高表达的MUC1可能参与了腺癌的恶性演进和侵袭转移。腺性膀胱炎和膀胱腺癌的MUC1表达特点可以作为临床病理鉴别诊断的依据。

Objective：To investigate MUC1 gene expression in cystitis glandularis and adenocarcinoma and to evaluate its significance for biological behavior, to offer assistance to clinical pathologic diagnosis. Methods： MUC1 gene expression was detected in 20 specimens of mucous membrane of urinary bladder, 20 specimens of cystitis glandularis and 10 specimens of adenocarcinoma by immunohistochemistry. Result： MUC1 gene expression was positive in normal epithelium, cystitis glandularis and adenocarcinoma. Each of their expression mode has its own characteristic. Strong expression of MUC1 gene was observed only in cystitis glandularis and adenocarcinoma. The staining patterns were significantly associated with cell hyperplasy and tumor cell differentiation （ P 〈0. 001）. Conclusion： Overexpression of MUC1 hints active epithelium metabolism and proliferation, but not a canceration mark. Each expression characteristic is useful in diferential diagnosis. The highly expressed MUC1 could play an important role in tumor infiltration and metastasis.