肠易激综合征血浆中胃肠激素的变化及其意义

GASTROINTESTINAL HORMONES IN PLASMA IN IRRITABLE BOWEL SYNDROME

应用放射免疫分析法检测正常对照组２４例及肠易激综合征组（ＩＢＳ）２６例受检者血浆中胃肠激素的浓度，旨在探讨ＩＢＳ病人血浆中胃肠激素有无变化及它们在ＩＢＳ发病中的可能作用和临床意义。结果：ＩＢＳ组血浆中胆囊收缩素（ＣＣＫ）、胃动素（ＭＴＬ）和生长抑素（ＳＳＴ）的浓度明显高于正常对照组（Ｐ＜０．０５）。提示血浆中ＣＣＫ、ＭＴＬ和ＳＳＴ可能参与ＩＢＳ的发病或病理生理过程，建议在临床实验诊断中验证它们作为ＩＢＳ诊断标志的可能性。

The aim of this study is to investigate the possible role and the clinical significance of the plasma gastrointestinal hormones in the irritable bowel syndrome(IBS).The plasma gastrointestinal hormones in the normal group( n =24) and the IBS group( n =26) were measured by the radioimmunoassay(RIA).The results revealed that the plasma cholecystokinin(CCK),motilin(MTL) and somatostatin(SST) in the IBS group were significantly higher than those in the normal group( P <0 05) and that the plasma substance P(SP) in both groups was not significant different ( P >0 05).The increases of the plasma CCK,MIL and SST in the IBS indicate that these hormones may play some roles in the genesis of the IBS or its development.These hormones as possible diagnostic markers of the IBS in chinical experiments need to be studied.