胃癌及其淋巴转移灶β4整合素表达的临床意义

CLINICAL SIGNIFICANCE OF β 4 INTEGRIN EXPRESSION IN GASTRIC CANCER AND ITS LYMPHATIC METASTASIS.

应用免疫组化方法观察了１４例胃癌患者原发灶、转移或非转移性淋巴结及邻近正常胃粘膜等不同组织的利亚单位表达情况，发现原发灶的表达显著强于邻近正常胃粘膜（Ｐ＜０．０５），并且依肿瘤的生长方式、分化程度及淋巴转移状况的不同，β４的表达强度有明显差别（Ｐ＜０．０１～０．０５）；而癌转移性或非转移性淋巴结中β４的表达均呈异质性减弱或基本消失。

By immunohistochemical staining,expression of β 4 subunit was investigated in different tissues from 14 patients with gastric cancer(GC),which include primary GC,lymph nodes with or without metastasis and normal gastric mucosa adjacent to the tumour. β 4 was dramatically( P <0 05) expressed in primary GC than that of normal gastric mucosa,and there were significant differences ( P <0 01～0 05) between different groups depending upon growth ways,differentiation,and lymph way metastasis respectively.But no β 4 expression was found in lymph nodes with or without metastasis.Results suggested that higher expression of β 4 of GC cells is closely correlated with their invasive growth,lower differentiation and metastatic tendency by lymph circle,and its low expression might also play an important role in their lymph metastasis.