摘要
采用3H标记的α-氨基异丁酸(3H-AIB)做为血脑屏障(BBB)通透性指示剂,定量观察了高血糖大鼠脑缺血后BBB的变化。结果发现,在大鼠4血管阻断脑缺血20min,高血糖组BBB通透性明显高于正常血糖组及非脑缺血对照组;正常血糖组与对照组间无明显差异。提示高血糖能够加重BBB损害,BBB的损害可能是高血糖加重脑缺血性损害及脑水肿的重要病理生理机制之一。
Clinical and experimental date indicate that hyperglycemia can aggravate the consequences of cerebral ischemia.Because breakdown of blood brain barrier(BBB) play an importment role in cerebral ischemia, using ( 3H)α aminoisobutyric acid( 3H AIB) as a passive permeability marker, we quantitatively studied the permeability of BBB to 3H AIB in hyperglycemic rats undergoing 20 minutes of four vessel occlusion followed by 12 minutes of postischemic recirculation.The result showed that the permeability of BBB to 3H AIB was significantly increased in hyperglycemic rats compared with normoglycemic and control group. This finding indicates that hyperglycemia significantly worsens the degree of BBB injury.Postischemic BBB disruption may play an importment role in the pathogenesis of increased brain damage associated with hyperglycemia.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1996年第5期359-360,共2页
Medical Journal of Chinese People's Liberation Army
关键词
高血糖
脑缺血
血脑屏障
hyperglycemia
cerebral ischemia
blood brain barrier
rat〖