抑制一氧化氮后内皮素对冠脉血流及内皮功能的影响

EFFECTS OF INTRACORONARY ENDOTHELIN PERFUSION ON HEMODYNAMICS AND ENDOTHELIN DEPENDENT DIASTOLIC FUNCTION OF CORONARY ARTERIES AFTER INHIBITION OF NITRIC OXIDE IN ANESTHETIZED DOGS

观察了犬冠脉内灌注内皮素－１（ＥＴ－１）、Ｎ－单甲基左旋精氨酸（Ｌ－ＮＭＭＡ）＋ＥＴ－１和单独灌注Ｌ－ＮＭＭＡ前后各自的血流动力学和内皮依赖性舒张功能改变。结果发现，灌注Ｌ－ＮＭＭＡ后，ＥＴ－１使静息冠脉流量、冠脉储备、左室收缩压（ＬＶＳＰ）明显下降，主动脉压、左室舒张末压（ＬＶＥＤＰ）明显升高，乙酰胆碱（Ａｃｈ）不再使冠脉血流量增加。提示内源性一氧化氮（ＮＯ）形成受抑制后ＥＴ－１的血管收缩作用明显增加，并引起心肌舒缩功能和心电活动的改变。

Changes in hemodynamics and diastolic function of coronary arteries were observed before and after intracoronary perfusion of endothelin(ET),N monomethyl L arginine (L NMMA),and ET and L NMMA.The results showed that resting coronary blood flow,coronary storage and LVSP were decreased significantly while LVEDP was noticeably increased by ET after perfusion of L NMMA,and that coronary blood flow was not increased by acetycholine.These data support the view that inhibition of endogenous nitric oxide augments the vasoconstrictive effect of ET.