人促红细胞生成素对肾缺血再灌注损伤的保护作用

Protective activity of human erythropoietin against renal ischemia-reperfusion injury

目的探讨促红细胞生成素(erythropoietin,Epo)对失血性休克大鼠肾损伤的保护作用。方法建立失血性休克大鼠肾损伤模型,分为对照组、休克组及Epo治疗组3组,进行组织学观察,并检测血丙二醛(MDA)、肌酐(Cr)、素氮(BUN)和肾组织匀浆超氧化物歧化酶(SOD)、白介素-6(IL-6)水平。结果Epo治疗组血浆MDA、Cr、BUN水平较失血性休克组组显著下降(P<0.05);肾组织匀浆SOD显著升高、IL-6显著降低(P<0.05)。结论Epo可提高SOD,降低IL-6,对肾缺血再灌注损伤具有保护作用。

Objective To study the protective effect of erythropoietin （Epo） on renal ischemia-reperfusion （I/R） injury, following hemorrhagic shock in rats. Methods The rat model of renal I/R injury following hemorrhagic shock was established. Thirty-six SD rats were divided into three groups： control group （group 1, n = 12）, shock group （group 2, n = 12）, and Epo treatment group （group 3, n = 12）. Plasma malondialdehyde （MDA）, Cr, blood urea nitrogen （BUN）, tissue SOD, and IL-6 of rats in the three groups were observed. Results Plasma MDA, Cr, BUN, and tissue IL-6 of Epo group were significantly lower than those of shock group, but SOD was significantly higher compared with shock group. Conclusion Epo has a protective effects on renal I/R injury following hemorrhagic shock in mrs because it can increase SOD and decrease IL-6.