期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

β-淀粉样斑块显像剂的研究 被引量：2

Advances in Imaging Agents for β-Amyloid Plaques
下载PDF
导出
摘要 阿尔茨海默病(AD)是一种脑神经退变性疾病。在AD发病机理方面,脑中β-淀粉样斑块的形成是一个主要因素,β-淀粉样斑块显像剂对于AD的早期诊断具有重要的临床意义。结合本实验室工作,本文介绍了β-淀粉样斑块显像剂的发展过程和目前国内外的最新进展,并对β-淀粉样斑块显像剂的未来发展方向作了展望。 Alzheimer＇s disease （AD） is a kind of degenerative neurodisease. The formation of β-amyloid plaques in brain is one of the main factors in developing of AD. Imaging agents for β-amyloid plaques are of great significance to early diagnosis of AD. The recent advances in imaging agents for β-amyloid plaques domestic and abroad as well as work in my laboratory are reviewed in this paper. The trend for developing β-amyloid plaques imaging agents is also discussed.
作者 陈祥纪
机构地区 北京师范大学化学学院放射性药物教育部重点实验室
出处 《化学进展》 SCIE CAS CSCD 北大核心 2007年第1期123-129,共7页 Progress in Chemistry
基金 国家自然科学基金项目资助(No.20471011)
关键词 阿尔茨海默病 β-淀粉样斑块 显像剂 Alzheimer＇ s disease （AD） β-amyloid plaques imaging agents
分类号 O615.4 [理学—无机化学] O628 [理学—有机化学]
  • 相关文献

参考文献53

  • 1Mathis C A, Wang Y, Klunk W E. Cur. Pharm. Des., 2004,10 : 1469-1492
  • 2王武尚,张锦明,刘伯里.AD脑Aβ放射性显像剂的研究进展[J].同位素,2004,17(4):232-240. 被引量：8
  • 3Majocha R E, Reno J M, Friedland R P, et al. J. Nucl. Med.,1992, 33:2184-2189
  • 4Friedland R P, Majocha R E, Reno J M, et al. Mol. Neurobiol.,1994, 9:107-113
  • 5Friedland R P, Kalaria R, Berridge M, et al. Ann. NY Acad.Sci., 1997, 826:242-247
  • 6Bickel U, Lee V M, Trojanowski J Q, et al. Bioconjugate Chem., 1994, 5:119-125
  • 7Mayo J E, Stimson E R, Ghilardi J R, et al. Proc. Natl.Acad. Sci. USA, 1992, 89:5462-5466
  • 8Saito Y, Buciak J, Yang J, et al. Proc. Natl. Acad. Sci. USA,1995, 92:10227-10231
  • 9Ghilardi J B, Carton M, Stimson E B, et al. Neuroreport, 1996,7:2607-2611
  • 10Lee H J, Zhang Y, Zhu C, et al. J. Cereb. Blood Flow Metab.,2002, 22:223-231

二级参考文献55

  • 1Hardy J, Selkoe D J. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics[J]. Science, 2002,295:353-356.
  • 2Selkoe D J. Imaging Alzheimer's Amyloid[J]. Nature Biotechnol, 2000,18(7):823-824.
  • 3Klunk W E, Wang Y, Huang G F, et al. Uncharged Thioflavin-T Derivatives Bind to Amyloid-beta Protein With High Affinity and Readily Enter the Brain[J]. Life Sci, 2001,69(13):1 471-1 484.
  • 4Wang Y, Klunk W E, Huang G F, et al. Development of 123I-Labelled Agents for Amyloid Imaging[J]. J Labelled Cpd Radiopharm, 2003, 46(S1): S173(Abstract).
  • 5Wang Y, Klunk W E, Huang G F, et al. Synthesis and Evaluation of a Radioiodinated Benzothiazole Derivative as a Radiologand for in vivo Quantitation of Beta-amyloid Deposits in Aging and Alzheimer's Disease[J]. J Labelled Cpd Radiopharm, 2001,44(S): S239
  • 6Wang Yanming, Klunk W E, Huang Guo-feng, et al. Synthesis and Evaluation of 2-(3′-Iodo-4′-aminophenyl)-6-hydroxybenzothiazole for in vivo Quantitation of Amyloid Deposites in Alzheimer's Disease[J]. J Molecular Neuroscience, 2002,19(1):11～16.
  • 7Chester A Matis, Brian J Bacski, Stephen T Kajdasz, et al. A Lipohilic Thioflavin-T Derivative for Positron Emission Tomography (PET) Imaging of Amyloid in Brain[J]. Bioorg Med Chem Lett, 2002,12:295-298.
  • 8Wang Y, Klunk WE, Huang GF, et al. Development of 123I-labelled Agents for Amyloid Imaging[J]. J Labelled Cpd Radiopharm, 2003, 46: S173.
  • 9Vanderghinste D, Eeckhoudt MV, Cleynhens J, et al. Synthesis and Preliminary Evaluation of 99mTc-BAT-thioflavine T Derivatives for in Vivo Visualization of Amyloid β[A]. Nicolini M, Mazzi U. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine[C]. Italy: SGE, 2002. 463～465.
  • 10Pelecanou M, Pirmettis I, Patsis G, et al. Tricarbonyl Complexes of Re and Tc With a Bifunctional Tridentate NNO Ligand Carrying the 2-Phenyl-Benzothiazole Moiety[J]. J Labelled Cpd Radiopharm, 2003, 46: S25.

共引文献8

同被引文献2

引证文献2

化学进展
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部