呼吸道合胞病毒毛细支气管炎血清维生素A水平的变化

SerumvitaminAlevelinbronchiolitiswithrespiratorysyncytialvirusinfection

为探讨血清维生素Ａ水平与呼吸道合胞病毒（ＲＳＶ）所致下呼吸道感染之间的关系，采用对照研究方法，对４６例确诊为ＲＳＶ感染的毛细支气管炎患儿的急性期（０，７天）和恢复期（≥１５天）血清维生素Ａ值进行动态观察，并比较急性期轻症与重症患儿血清维生素Ａ水平的差异。结果：急性期维生素Ａ值为０．９４±０．１５μｍｏｌ／Ｌ（ｘ±ｓ）与对照组比较（１．４７±０．３０μｍｏｌ／Ｌ）差异有极显著意义（ｔ＝９．９２，Ｐ＜０．０１）；恢复期维生素Ａ值为１．３８±０．３０μｍｏｌ／Ｌ，与对照组比较差异无显著意义（ｔ＝１．３１，Ｐ＞０．０５）；急性期重症患儿２０例中有１２例（６０．０％）血清维生素Ａ低于正常对照组血清维生素Ａ均值减２个标准差，而轻症患儿２６例中仅５例（１９．２％）低于此值，两组比较差异有极显著意义（χ２＝８．０６，Ｐ＜０．０１）。提示：ＲＳＶ毛细支气管炎急性期血清维生素Ａ水平明显低于正常对照组，疾病恢复期血清维生素Ａ呈回升趋势；急性期血清维生素Ａ下降程度与疾病严重程度呈平行关系。

ToexploretherelationbetweenvitaminAandlowerrespiratoryinfectioncausedbyrespiratorysyncytialvirus(RSV)confirmedbyantigentestand(or)viralculture,westudied46cas-esofbronchioltiswithRSVinfectionand26controls.SerumvitaminAlevelof46patientsduringa-cuteilness(day0,7),convalescence(day15)andofcontrolinfantsweremeasured.SerumvitaminAlevelbetweenmildandseverepatients(Lowel′scriterion)wasalsocompared.TheresultsshowedthatserumvitaminAlevelatacutestage,convalescenceofilnessandcontrolswas0.94±0.15μmol/L,1.38±0.30μmol/Land1.47±0.30μmol/L,respectively.Twelveseverecasesoutof20(60%)hadserumvitaminAlevelbelowthemeanminus2SDofthevalueofcontrolinfants,whereasonly5mildpatientsoutof26(19.2%)hadvitaminAlevelbelowsuchvalue(χ2=8.06,P<0.01).TheresultsofthisstudyindicatethatserumconcentrationofvitaminAdecreasesatacutestageofilnessandisspontaneouslyrecoveredatconvalescence.ThedegreeofthedecreaseinserumvitaminAata-cutestageofbronchiolitiswasassociatedwiththeseverityofilness.