生殖道感染就诊妇女与健康体检妇女中支原体感染状况的调查

Study on the Mycoplasma infection status between healthy women and women with gential tract inflammation

目的了解解脲脲原体（Uu）、人型支原体（Mh）在生殖道感染妇女和健康体检妇女中的感染状况。方法采集2005年11月至2006年4月南京市某三甲医院就诊的生殖道感染女性184例和健康体检女性199名的生殖道分泌物样本，同时采用培养法和聚合酶链反应法进行Uu、Mh的检测，在培养的同时采用倍比稀释法进行颜色变化单位（CCU）浓度检测，并结合调查表资料，对两组人群的支原体感染状况进行分析。结果生殖道感染人群支原体阳性率76．1％，显著高于健康女性人群42．2％（x^2=45．1862，P〈0．0001）。健康女性以单纯Uu和单纯Mh感染为主，生殖道感染者以Uu和Mh的混合感染为主（单纯Uu、Uu＋Mh：x^2=39．5956，P〈0．0001；单纯Mh、Uu＋Mh：x^2=13．2935，P=0．0003）。支原体CCU浓度检测结果显示，生殖道感染女性人群体内Uu、Mh浓度显著高于健康体检人群（Uu：秩和检验Z=7．1058，P〈0．0001，Mh：秩和检验Z=8．7201，P〈0．0001）。支原体在各年龄段普遍易感。结论两种支原体均为条件致病菌，两者并存具有一定的协同致病作用，当支原体感染量较高时易导致临床症状的出现。

Objective To study and compare the pathogenicity and pathogenic condition of Ureaplasrna urealyticum （Uu） and Mycoplasrna hornonis （Mh） between healthy women and women with gential tract inflammation. Methods To collect the gential tract secretion in the two groups and detect the infectious ratio and color change unit （CCU） concentration. Together with data gathered from questionnaires, we studied the mycoplasma infectious status between the two kinds of people. Results The positive rate was 76.1% in women with gential inflammation, higher than in healthy women whose positive rate was 42.2 % （ X2 = 45. 1862, P〈 0. 0001）. Mixed infection of Uu and Mh was popular in infected women. Healthy women were easier to be infected by Uu or Mh（Uu, Uu ＋ Mh：X^2 = 39. 5956, P 〈 0. 0001 ; Mh,Uu ＋ Mh： X^2= 13.2935, P= 0.0003）. The result of CCU concentration showed the infected concentration in women with gential tract inflammation was higher than healthy women（ Uu：Z = 7. 1058, P〈0.0001; Mh： Z= 8.7201, P〈 0.0001）. Uu and Mh were commonl sensitively in every age. Conclusion Both Uu and Mh were conditioned pathogens. The two kinds of mycoplasma had cooperated pathogenic effects which was easily leading to clinical symptom in the high infectious concentration.