摘要
观察佤药灯台树对博莱霉素诱导的大鼠肺泡炎早期的防治作用。以博莱霉素气管内注射建立肺纤维化模型,第二天分别给与灯台树和强的松灌胃治疗,于给药第7d、14d处死动物,右肺组织行病理组织学检查,左肺组织匀浆进行超氧化物歧化酶(SOD)活力、丙二醛(MDA)、谷胱甘肽(GSH)、肿瘤坏死因子(TNf-α)含量检测。结果与博莱霉素对照组相比:各治疗组肺泡炎的程度均明显减轻;7d时灯台树组肺组织匀浆MDA、TNF-α含量降低(P<0.05),强的松组肺组织匀浆GSH含量升高(P<0.05);14d时灯台树、强的松组肺组织匀浆SOD活力、GSH含量均增高(P<0.05),MDA含量降低(P<0.05)。证明灯台树水煎液可以增强SOD的活性,提高清除氧自由基能力,减轻脂质过氧化物损伤,维持氧化/抗氧化平衡。对肺损伤后早期肺泡炎阶段具有显著治疗作用。
To study the effect of Alstonia scholaris on early experimental pulmonary fibrosis in rats with Bleomycin（BL） -induced, all rats were randomly divided into four groups and given BL endotracheally except the normal control group. On 2 d, each BL group was given Alstortia scholaris, and Hydrpnredniosone respectively except BL control group. On 7 d, 14 d, 6 rats of each group were killed and lungs were harvested respectively. The fight lungs were for histopathological studies （HE staining）, the left lungs were homogenized for biochemical assays of SOD activity and MDA, GSH, TNF-α content. It is obtained that compared to BL group： aleveolitis were alleviated in each treated group significantly;on 7 d, MDA,TNF-α contents of homogenized lungs in Alstonia scholaris decreased （ P 〈 0.05 ）, Hydrpnredniosone group increased （P 〈 0. 05 ） ; on 14 d, SOD GSH contents of homogeniszed lungs in each treated group increased （ P 〈 0. 05 ）, MDA contents decreased （P 〈 0.05 ）. It is proved that ： solution of Alstonia scholaris could heighten the activity of SOD, lower damnification of LPO, enhance the power of eliminating Oxygen radical, keep the balance of oxidation/deoxidation, Solution of Alstonia scholaris have the better therapy during the early aleveolitis phase in the development of pulmonary fibrosis.
出处
《科学技术与工程》
2007年第1期41-45,72,共6页
Science Technology and Engineering
关键词
灯台树
博莱霉素
肺泡炎
肺纤维化
Alstonia scholaris Bleomycin pulmonary alveolitis pulmonary fibrosis
