呋塞米固态分散体处方与溶出度的研究

Formulaanddisolutionoffurosemidesoliddispersion

目的：提高难溶药物呋塞米（ＦＤ）的溶出度。方法：筛选ＰＶＰ、玉米淀粉作载体，以磷酸氢二钠－枸橼酸缓冲系统来控制微环境ｐＨ值，用溶剂沉降法将ＦＤ制成固态分散体，进而制成胶囊剂。结果：Ｘ射线衍射实验表明，此固态分散体中ＦＤ为无定型、无结晶。其胶囊剂与普通片剂比较，溶出度显著提高。

OBJECTIVE:Toimprovethedissolutionofinsolublefurosemide(FD).METHOD:PVPandcorn-starchwereselectedascarrier,buffersystemsodiumphophatedibasicanhydrous(Na2HPO4)andcitricacidtocon-trolmicroenvironmentpH.SoliddispersionwasmadeupofFDusingsolventsetlemethod,whichwsfurtherman-ufacturedintocapsules.RESULTS:X-raydifractionmethodsshowedthatFDwasnumerouscrystalsexistinginthesoliddispersion.Comparedwithtablet,thedissolutionwashigherapparently.CONCLUSION:DissolutionofFDcouldbeincreasedbysoliddispersion.